It is an interesting concept nonetheless! Though if there were to be a sequel, I'd rather it have another pony as the protagonist. Don't get me wrong, I love Littlepip and want to hug her all the time, but I think she has been through enough for one life. A pony can only go so far, and give so much. I really just want to friggin hug her.
I know it says "not inspired by dead space 3," but I just realized something: the original Borderlands was pretty wasteland-y and lacked any snow. Borderlands 2: half of the map is a frozen tundra. FO:E was hot and wasteland-y, whereas every fan art of FO:E2 has included snow. Coincidence? I think not.